New Carsil forte capsules 90mg №30 View larger

Carsil forte capsules 90mg №30

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Capsules

Composition

1 caps. Contains Milk thistle spotted fruit extract dry 163.6-225 mg (equivalent to the content of silymarin 90 mg)

Packing

30 pieces

Mechanism of action

Carsil Forte belongs to the group of hepatoprotective drugs. Contains dry extract of the fruits of milk thistle (equivalent of silymarin), which is a mixture of 4 isomers of flavonolignan: silibinin, iso-silibinin, silidianin and silicristin.

The mechanism of action of the drug is still insufficiently clarified. It has been established that the hepatoprotective effect of silymarin is due to competitive interaction with toxins on the corresponding receptors in the hepatocyte membrane, thus manifesting membrane stabilizing action.

Silymarin has metabolic and cell-regulating effects, regulating cell membrane permeability, inhibiting the 5-lipoxygenase pathway, especially LT.4, as well as binding to free oxygen reactive radicals. Stimulates the synthesis of proteins (structural and functional) and phospholipids in affected hepatocytes, accelerating regenerative processes. The action of flavonoids, to which silymarin belongs, is also due to their antioxidant and microcirculation-improving effects.Clinically, these effects are expressed in the improvement of subjective and objective symptoms and in the normalization of indicators of the functional state of the liver (transaminases, γ-globulin, bilirubin). This leads to an improvement in the general condition, a decrease in complaints related to digestion, and in patients with reduced digestion due to liver disease, an increase in appetite and an increase in body weight.

Indications and usage

In the complex therapy:

  • toxic liver damage,
  • conditions after acute hepatitis,
  • chronic hepatitis non-viral etiology,
  • liver steatosis (non-alcoholic and alcoholic),
  • cirrhosis of the liver,
  • prevention of hepatic lesions with long-term medication, alcohol, chronic intoxication (including professional).

Contraindications

  • hypersensitivity to the active or any of the excipients of the drug Carsil Forte,
  • lactase deficiency, galactosemia or glucose / galactose malabsorption syndrome (the presence of lactose in the formulation),
  • celiac disease (gluten enteropathy) - the presence of wheat starch in the preparation,
  • children under 12 years old.

Carefully: patients with hormonal disorders (endometriosis, uterine fibroids, carcinoma of the mammary gland, ovaries and uterus, carcinoma of the prostate gland) - estrogen-like effect of silymarin is possible.

Dosage and administration

Carsil Forte must be ingested with enough water.

Adults and children over 12 years old: treatment of severe liver damage begins with a dose of 1 caps. 3 times a day.

In milder and moderate cases, the dosage is 1 capsule. 1-2 times a day.

For the prevention of chemical intoxication - 1-2 caps. in a day.

The course of treatment is at least 3 months.

Children under 12 years old: There is insufficient clinical data to apply.

Adverse reactions

The drug is well tolerated. The following side effects are rarely observed.

From the digestive tract: nausea, dyspepsia, diarrhea.

From the skin: in rare cases, allergic skin reactions are possible - itching, rash, alopecia.

Others: it is rare to observe an increase in existing vestibular disorders.

Side effects are transient in nature and disappear after stopping the drug.

Drug Interactions

When combined use of silymarin with oral contraceptives and drugs that are used in hormone replacement therapy, it is possible to reduce the effects of the latter.

Silymarin can enhance the effects of drugs such as diazepam, alprazolam, Ketoconazole, lovastatin, vinblastine, due to its overwhelming effect on the cytochrome P 450 system.

Storage conditions

In a dry, dark place at a temperature of no higher than 25 ° C.

2 years.

Carsil forte