Nolpaza pills 20 mg №28 Нольпаза Пантопрозол 28 таблеток
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- gastroesophageal reflux disease (GERD), incl. Erosive and ulcerative reflux esophagitis and symptoms associated with GERD: heartburn, acid regurgitation, pain when swallowing,
- erosive and ulcerative lesions of the stomach and duodenum, associated with the intake of NSAIDs,
- peptic ulcer of the stomach and duodenum (treatment and prevention),
- eradication of Helicobacter pylori in combination with two antibiotics,
- Zollinger-Ellison syndrome and other pathological conditions associated with increased gastric secretion.
hypersensitivity to pantoprazole or other components Nolpazy,
the drug contains sorbitol, therefore it is not recommended for persons with a rare hereditary fructose intolerance,
children's age up to 18 years (efficiency and safety are not studied).
Carefully: pregnancy, lactation, liver failure, risk factors for cyanocobalamin deficiency (vitamin B12), especially against the background of hypo- and achlorhydria.
Inside, the pill should not be chewed and broken. The pill is swallowed whole, washed down with a small amount of liquid, before meals, usually before breakfast. When taking a double dose of the second dose Nolpazy recommended before dinner.
The recommended dose - 1 table. Nolpazy on 20 mg per day.
The side effects of the WHO classification are as follows:
From the side of blood formation organs: very rarely - leukopenia, thrombocytopenia.
From the digestive system: often - abdominal pain, diarrhea, constipation, flatulence, infrequently - nausea, vomiting, rarely, dry mouth, very rarely, increased activity of hepatic transaminases and gamma glutamine transferase (GGT), severe liver damage, leading to jaundice with or without liver failure.
The immune system: very rarely - Anaphylactic reactions, including anaphylactic shock.
Musculoskeletal system: rarely - arthralgia, very rarely - myalgia.
From the central and peripheral nervous system: often - headache, infrequently - dizziness, blurred vision (blurred vision).
Mental disorders: very rarely - depression.
Urogenital: very rarely - interstitial nephritis.
Allergic reactions: Infrequently - itching and rash, very rarely - urticaria, angioedema, Stevens-Johnson syndrome, erythema polymorphism or Lyell's syndrome, photosensitization.
Common disorders: Very rarely - peripheral edema, hyperthermia, weakness, painful breast tension, increased triglyceride levels.
With the development of severe adverse effects, treatment with Nolpaza should be discontinued.
Nolpase reduces the absorption of drugs, the bioavailability of which depends on the pH of the stomach and absorbed at acidic pH values (eg, ketoconazole).
Pantoprazole is metabolized in the liver by the cytochrome P450 enzyme system. Pantoprazole interactions with drugs that are metabolized by the same system cannot be ruled out. However, in clinical studies, no significant interactions were found with Digoxin, diazepam, Diclofenac, ethanol, phenytoin, glibenclamide, Carbamazepine, caffeine, Metoprolol, Naproxen, Nifedipine, Piroxicam, theophylline, and oral contraceptives.
Although with simultaneous use with Warfarin in clinical pharmacokinetic studies, no significant interactions were found, several separate reports of a change in MHO were noted.In patients receiving coumarin anticoagulants, simultaneously with pantoprazole, it is recommended to regularly monitor the prothrombin time or MHO.
While taking pantoprazole with antacids, no drug interactions have been registered.
Symptoms of an overdose in humans are not known.
Treatment: there is no specific antidote. In the case of an overdose of the drug, accompanied by the usual signs of intoxication, detoxification measures are used. Symptomatic treatment.
The drug should be stored out of the reach of children at a temperature not higher than 30 ° C.